Continous Infusion of Ifosfamide without Mesna to prevent Hemorrhagic Cystitis.
نویسندگان
چکیده
منابع مشابه
Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis.
OBJECTIVE To investigate the possible protective effect of recombinant human interleukin-11 (rhIL-11) against ifosfamide (IFS)-induced hemorrhagic cystitis (HC). MATERIALS AND METHODS Male Swiss mice (20-30g) were pretreated with rhIL-11 (25-625 mg, subcutaneously.) 30 min before intraperitoneal injection of IFS (400 mg/kg) or with saline (control group). Twelve hours later, HC was evaluated ...
متن کاملPrevention and treatment of cyclophosphamide and ifosfamide-induced hemorrhagic cystitis
Free radicals and non-radical reactive molecules as well as several cytokines (e.g. tumor necrosis factor-α and interleukin family) and transcription factors (e.g. nuclear factor-κB and activator protein-1) are now known to take part in the pathogenesis of cyclophosphamide (CP) and ifosfamide (IF) induced hemorrhagic cystitis (HC). When these molecular factors are taken into account pathogenesi...
متن کاملMesna Excretion and Ifosfamide Nephrotoxicity in Children1
To characterize the excretion of 2-mercaptoethanesulfonate sodium (mesna) administered by intermittent infusion, urinary concentrations of mesna and its corresponding inactive disulfide »eremeasured during 50 courses of ifosfamide (1.6 g/nr for 5 days) and mesna (400 mg/nr at 0.25, 4, and 6 h after each ifosfamide dose) administered i.v. to 19 patients. Some patients had previously received ne...
متن کاملComparison of uroprotective efficacy of mesna and amifostine in Cyclophosphamide- induced hemorrhagic cystitis in rats.
BACKGROUND Hemorrhagic cystitis (HC) is a dose limiting side effect of cyclophosphamide (CYP). AIM In this study, we aimed to investigate the role of amifostine in the protection of CYP-induced HC and compare its efficacy with mesna. SETTING AND DESIGN This animal study was conducted in the Experimental Animals Breeding and Research Center of the Medical Faculty of Uludag University. MATE...
متن کاملIntravenous ifosfamide/mesna is associated with depletion of plasma thiols without depletion of leukocyte glutathione.
Depletion of cellular glutathione (GSH) enhances the efficacy of many anticancer agents in preclinical systems. Limited published data showing depletion of GSH in vitro and in patients by ifosfamide and/or mesna provided the rationale for a Phase I trial. Ifosfamide and mesna were infused over 24 and 36 h, respectively, at equal daily doses; carboplatin was given after ifosfamide to a target pl...
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ژورنال
عنوان ژورنال: Orthopedics & Traumatology
سال: 1992
ISSN: 1349-4333,0037-1033
DOI: 10.5035/nishiseisai.41.516